Sodium Cromoglycate (Cromolyn Sodium): A Review of its Mode of Action, Pharmacology, Therapeutic Efficacy and Use

Reviewed date: Haven't looked into yet

Uploaded date: March 4, 2024


Why I'm interested:  

Sodium Cromoglycate (Cromolyn Sodium) is a mast cell stabilizer and helpful to reduce reactions, especially those triggered by allergy. Focuses on asthma a lot.

Source Information

Publication date: 1974

Source Type: Literature review

Original source/Referenced in: 

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Author Abstract:

Sodium cromoglycate (cromolyn sodium; FPL 670)2 is a synthetic bischromone derivative advocated for use in the prophylaxis and adjunctive management of bronchial asthma. It is not intended for the treatment of acute attacks. Sodium cromoglycate does not possess direct anti-inflammatory or bronchodilator properties, but when inhaled prior to antigen bronchial challenge in asthmatic subjects it inhibits at least partially, the development of an allergic bronchial reaction.

Sodium cromoglycate is believed to act by stabilisation of mast cell membranes, thereby inhibiting the release of pharmacological mediators of anaphylaxis when the cells are triggered in a selective manner. In experimental studies in allergic subjects, sodium cromoglycate has been shown to inhibit the development of both immediate and late antigen-induced asthmatic reactions; in contrast, corticosteroids whether given orally or by inhalation, inhibit only the late response.