Regional changes in brain histamine levels following dietary-induced thiamine deficiency in rats

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Uploaded date: March 17, 2024

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Why I'm interested:  

These data present a new finding that thiamine deficiency affects the central histaminergic neuron system as well as other monoaminergic systems.

Can supplementing with thiamine result in better histamine and allergic reactions?

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Source Type: Original research article

Author Abstract:

Histamine levels in thiamine deficient rats were significantly lower in the hippocampus, amygdala, olfactory bulb, thalamus and pons-medulla oblongata than those of normal and pair-fed groups. In the case of the hypothalamus, thiamine deficiency produced a significant increase in histamine levels. These changes observed in the thiamine deficient group were reversed to the normal levels by supplying the normal diet. These data present a new finding that thiamine deficiency affects the central histaminergic neuron system as well as other monoaminergic systems.

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