More thiamine/histamine articles to sort through

Reviewed date: Haven't looked into yet

Uploaded date: March 17, 2024

Thoughts

Why I'm interested:  

From forum: https://www.celiac.com/forums/topic/156835-thiamine-deficiency-and-histamine-intolerance-is-there-a-link

Effects of thiamine administration on hypothermia and hypothalamic histamine levels in dietary-induced thiamine deficient rats

https://pubmed.ncbi.nlm.nih.gov/2090843/

"...the increased histamine levels in the hypothalamus, especially those in its anterior region, are closely related to the hypothermia in thiamine-deficient rats."

"What does the hypothalamus do?"

https://www.medicalnewstoday.com/articles/312628

Mast cells releasing histamine is part of the immune response to antigens like gluten, casein, or viruses like Covid.

 

Mast cells activated by SARS-CoV-2 release histamine which increases IL-1 levels causing cytokine storm and inflammatory reaction in COVID-19

https://pubmed.ncbi.nlm.nih.gov/32945158/

High dose Thiamine is used to quench the out of control immune response in Covid patients.

Repurposing Treatment of Wernicke-Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile.

https://europepmc.org/article/MED/33737877

"Thiamine, a very safe drug even at very high doses, could be repurposed for treating the Th17 mediated IL-17 immune storm, and the subsequent neurological symptoms observed in COVID-19. Further studies using thiamine as an intervention/prevention strategy in COVID-19 patients could identify its precise anti-inflammatory role."

Cobalamine, Vitamin C, Pyridoxine, and Folate help get rid of the histamine, while Thiamine helps calm the immune response. Niacin and Riboflavin are also needed to help the other B vitamins do their jobs. A B Complex supplement should contain all eight of the essential B vitamins. Thiamine needs magnesium to work properly, so a magnesium supplement would be beneficial.

Oh, there's calcium in cooked green leafy vegetables that is better absorbed than the calcium in dairy.

Liver is a great source of all the B vitamins and important minerals like iron and zinc.

 

I've recently been reading about anemia unresponsive to iron supplementation therapy actually may be copper deficiency.

Thiamine needs Magnesium to work properly, a co-factor.  Having Magnesium deficiency can affect how well the body can utilize Thiamine.  Thiamine is needed to make different types of blood cells.

Alteration in MDA, GSH level and hematological changes due to thiamine deficiency in Mus musculus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853013/

There's several posters who have said they have thalassemia and/or iron overload.

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