MCAS & Stabilizers

Reviewed date: Haven't looked into yet

Uploaded date: March 2, 2024

Thoughts

Why I'm interested:  

MCAS may be behind salicylate sensitivity. Rather than going with avoidance, manage the mast cells for fewer reactions.

Videos


Low-sal member forwarded a bunch of MCAS information to review (thank you!)

The application of this study is kind of weird, but it does discuss the greater bioavailability of water soluble quercetin.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581924/

Isoquercitin shows a consistently better performance as a supplement.

https://www.naturalmedicinejournal.com/journal/evaluating-bioavailability-isoquercetin

Dr Theo compared the effects of water soluble quercetin, quercetin, and cromolyn on mast cells. In other publications he says repeatedly that he thinks suspending it in oil is even better digestively, which is what his Neuroprotek formulations are.  

http://mastcellmaster.com/documents/Mastocytosis/Quercetin-better-than-cromolyn-PlosOne-2102.pdf

What is confusing is shopping for the supplement and deciphering the labels. EMIQ seems to be a trademark of a particular process, but as far as I can tell it is just a water-soluble form.  Other companies use the term Bioavailable.  Still others actually say Isoquercitin, or Alpha Glycosol Isoquercitrin.  Not having a background in chemistry, I don’t know how much of that is marketing and how much of it is actual chemical difference!

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This is a seminar I found on the internet of Tania Dempsey, that has the good description of the MCAS classifications that I read to you.  

She goes on to explain it more, how these people are kind of balanced on a knife’s edge, and can be doing okay until they are exposed to some trigger, and then they flare up.  The triggers can be very random, but the one thing that she finds most common in her patients is chemical sensitivity–not food chemicals, but man-made chemicals.  And this is what really connected with Kathy and caused her to buy into this possibility.

There is a screening tool they use that has three questions:

  1. Do you feel sick when you’re exposed to tobacco, smoke, certain fragrances, nail polish, gasoline, paint, paint thinners, cleaning supplies, new furniture, carpets? (headaches, difficulty thinking, difficulty breathing, weakness, dizziness, upset stomach)
  2. Are you unable to tolerate or do you have adverse or allergic reactions to drugs or medications like antibiotics, painkillers, contrast dye, birth control pills, implants, prostheses, etc.?
  3. Are you unable to tolerate or do you have adverse reactions to foods such as dairy, wheat, corn, eggs, soy, caffeine, or alcohol?

If a patient answers yes to at least two of those, they give them a longer, more detailed questionnaire (QEESI) about symptoms. You can find that at this website: tiltresearch.org

She also talks a good bit about testing and why looking for tryptase isn’t sufficient, and about treatment. Her take on it is that different treatments are going to work better on different people, depending on what they are sensitive to and what their mast cells are doing in there…but she told an interesting anecdote about cromolyn, that it stays in the gut and isn’t absorbed into the system, but the mast cells in the GI tract communicate to the nervous system, so she used it on a patient who could barely walk and it worked amazingly.

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Here is the transcript from the seminar.  Notice the times are marked, so if you need to see the chart or slide she is referencing, you can jump there in the video.

https://www.drtaniadempsey.com/post/mast-cell-activation-syndrome-the-interplay-between-immunity-and-neuroinflammation

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Source Information

Source Type: Info submitted by low-sal community member

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