Community Science Help! Fall 2022 Research Review

Join me through November and early December looking for relevant research review articles for future videos.  Email me at info@low-sal-life.com. Available to study on Monday nights and Saturday mornings (Pacific time/Seattle).

Directories to look for research articles

  • PubMed
  • Science Direct
  • Google Scholar

Other links

Research topics of interest (but not limited to)

  • Basics
  • All the different names and versions of salicylates
  • All the different bound salicylates (salicylates tied up with sugars and other complex compounds)
  • Levels in foods and plants
  • What is the process of salicylate breakdown in bodies (human or otherwise)
  • COX (1 or 2) and the breakdown of sals
  • By condition
  • IBS
  • Gluten intolerance/celiac
  • IBD: Chrons/diverticulitis
  • Mast Cell issues (MCAS)
  • Ezcemea
  • Psoriasis
  • Roceacea
  • Dermatitis (both contact, and seborreic)
  • Asthma
  • AERD
  • Nasal polyps
  • Acne
  • Muscle spasms, parkinsons, dystonia
  • Heart palpitations
  • Tinnitus and sound sensitivity
  • Aspirin toxicity (salicylism)
  • Hearing loss (from salicylism). Can hearing be affected in very small doses?
  • Anemia (iron-deficiency and other kinds)
  • Highly sensitive persons
  • Behavior/mental health affects
  • Kids and salicylates: adhd, autism/spectrum, nursing, etc.
  • Amine and histamine (allergy) overlaps
  • Low-stomach acid increases food sensitivity
  • Fragrance sensitivity
  • Genes related to histamine sensitivity (inability to break it down, or histamine migraines)
  • DAO in intestines – low vit C and iron issues, genes related to it
  • Sensitivity to epineprhine/adrenaline
  • -not related, but often mistake for oral allergy syndromes (especially birch and grasses)
  • chlorine sensitivity/swimming pools (chloramines)
  • Correlation with dust mite allergy
  • Chemical sensitivity
  • In production
  • animals and plants treated with salicyic acid
  • salicylic acid used in household products and plastics
  • salicylic acid used in personal products (feminine products) and plastics
  • Dipping fruits and veg in salicylic baths for prolonged shipping
  • Sals in dyes and fibers (clothes, boxes, papers, inks, etc)
  • Sals in wood and construction materials
  • Selecting for higher sals in beverages and food products
  • Effects of fermentation
  • By treatment
  • Supplements (iron, glycine, vit C, enzymes, DAO, sulphur, etc)
  • Desensitization (similar to allergy shots)
  • Antihistamines (include natural antihistamines – does vit C really work?)
  • Diet improvements (going vegetarian vs carnivore, keto?)
  • Food sensitivity improves with biofeedback
  • Sensitivity improves with breath holding and breathing exercise (Buteyko)
  • Elimination diet pros and cons (there is some research saying that elimination diets restrict foods after diet is done, even if there wasn’t a sensitivity before)
  • Wider net
  • other substances that sals folks also react to, but may not be a salicylate like soy
  • dyes and colors
  • fragrances
  • benzoates
  • other phenols
  • annatto
  • Orthorexia
  • Sensory Food Aversion or sensory processing disorder – sensitive to or gag on vegetable textures

Video Transcription

Provided for visual learners, improved accessibility, and for translating the page

00:00

Hello, welcome to low-sal-life. I’m Sarah. And today I I’ve thought all week about how are we going to make this video. First of all, welcome back. I am starting hibernation, which I do every year. So basically between November and February, I stay home and I work on projects. I work on research, I make videos, I think about life, I recharge, I’m introverted, I need that time. And the winter is a perfect time to just kind of escape things. And so I’ve been thinking a lot about getting up and going with some more low-sal videos. And thank you to all the new subscribers. So I was planning on maybe in another week or two starting up videos, I’ve been working on research and content for those. And this one here is going to get bumped in front of all of that other planning. And the reason why is because I was notified this week that something very drastic is happening. And I don’t know how to cope or handle it. And so my question to you is, if you would be willing to help me in our low sal research journey, and if you can help us out so what I was notified about this week is that my subscription through my work through my university is actually being canceled, and that is to the Elsevier journals. So any research that you guys haven’t been able to download or view or read, because it’s behind a paywall for research, I have had access to it free, because of my association with the University. As of January 1, I will no longer have that, because the university has decided not to renew their $2.6 million contract with this publishing company. And so that means that I will no longer have access to 2,800 journals. That’s not articles, journals, just the magazines like Science or Nature or any of those publications, I won’t have access to any longer. So this is a service that I’ve been a part of, fortunately, since probably about 2008, I’ve had access to it. And it’s, I kind of feel like there’s a little bit of grief associated with this, this week. Because anytime I’ve been like, I don’t know, do beans have salicylates? Like I can look that up, and then I can find behind a paywall the answer for all of us to finally get information on because nobody else is doing this. So I have felt very fortunate to have access to this. It’s been part of my -one of the major perks for my present, I’m at my work. And I just use it all the time. And we use it all the time and trying to uncover some of these answers like does fermentation increase or decrease salicylate levels and foods? I will tell you! It depends. But there’s definitely I just found last week an article that said fermentation a certain species of bacteria or fungi, that they can actually increase – break down bound salicylates and increase free salicylic acid in tea, for example. So I know that now, thanks to this service, I am much smarter. And so there’s a part of me, that is just freaking out. Yeah, it’s almost like being pulled off cold turkey off caffeine or another addictive substance. So I will have to do some life-analysis after January one. But for now, I have a plan.

03:51

On my research page, I have a growing list of research articles. A good portion of them are open source but a good portion of them are behind a paywall. Some of them I have pulled and just put at the bottom, there’s like 100 articles that are unsorted Uncategorized. I haven’t gone through those. But for the other articles, I have read and dropped in a review about them or like what are some strengths, other items behind paywalls I’ve done videos on or I plan to do videos on. So I have a good selection. I have all the most important articles, obviously my own collection. But there are so many questions that I have, and so many questions that you have. And you guys write me and say, Hey, I have MCAS. I’m wondering about this method, this this, this concept if it’s true or not, or if there’s a risk or whatever. I can look for the research articles and let you guys know what what the research says right? So basically, outside of like my normal life experiences, I don’t know what questions to look up or I don’t know like… I don’t know if there’s a correlation between iron deficiency anemia and aspirin sensitivity or salicylate sensitivity, or the breakdown of aspirin or consuming aspirin affects iron absorption, right? There’s a lot of little nuances in that. So, I’ve been thinking that maybe you guys might be able to help me out, build out a bibliography over the next six weeks, and I can download the articles, and then we can slowly digest them over the next few years. As I continue to make videos, that is the only solution I can think of. I was joking around my husband, I was like, order me a gaming chair. And like, I don’t know, I don’t drink Mountain Dew, but you know, basically, full supply of caffeine pills. And I’ll see you in January, because there’s just so many questions I have, and knowing that those items are no longer going to be available to me, like makes me feel like I’ve just been, like the air’s got gotten knocked out of me is how I feel. So as I tried to catch my breath, this is these are my thoughts. So I want to be clear that when I say we’re going to do research, we’re not going to do original research, right? We’re not going to run experiments or anything and write that type of thing. Right. So what we’re going to do is basically research review, we’re we’re looking for those research articles related to the topics we’re interested in. I am very interested in how the items we’re looking at, obviously support your agenda that yes, aspirin can ruin our lives, right? That’s basically what we’re trying to support. But I am also a big fan of also studying how aspirin benefits the body and how, you know, it reduces colon cancer. If you eat a high salicylates diet and how, you know, it can improve skin quality or decrease acne of use or skin stuff, right? Like how many of us have dandruff that we’re just trying to find something without salicylates in it to help control it. There’s a lot of good from that. But those studies that show how good aspirin is also show other things that we don’t understand about, like how aspirin is broken down in the body and how, you know, there’s certain genetics that you know, can help us understand better the full aspirin picture. So I am looking very broadly at the research articles that we could do, and look at.

Okay, so I believe that I am not going to look it up. I don’t think it’s that important. But I believe that the federal government a long time, I know that this is true for NSF National Science Foundation, but most federal… but most federal grants that are funded with federal dollars, those are supposed to be open sourced research now. And that’s where like, PubMed comes into, comes into the picture. So as far as any US research that’s federally funded, those are not at risk from us, like those were available to anybody in the world, fortunately, so that that’s good, those will remain open source, the items that end up being limited, and usually behind a paywall or anything that’s private, private research. And even those are kind of so so because like those might be pharmaceutical research. You know, stuff like that. So

08:49

sometimes they’re not very impartial. Then any articles that are really like before, I feel like articles that were published before like 1998 or 2000. Before the idea of open-source scholarship came into view. Those articles are almost impossible for me to find without being behind this paywall. So the last video I did like way back in April or May, about birches having salicylates in their pollen, I would not have been able to find that information and report out on it if it were not for an article behind a paywall. And then any articles that are published from international scholars now we know that salicylate sensitivity is basically like nonexistent here in the US. So all the other research that’s being done is international, currently. So that means I think it was Kęszycka, that some of the Polish articles, those are all behind a paywall so yeah, like this is a huge amount of the types of journals that help us get a better understanding of what salicylates are and how it affects us? It’s going to be, it’s going to be huge. Okay, I will stop rambling about the ramifications. And now let’s make a plan.

Okay, this is this is my plan for basically through mid-December, because somebody actually has to scan these articles and send them back to me, or at least manually download them or do something, I have to request them and it takes about two business days. And then of course, we have holiday. So I’m hoping by December 10, or so that I can have a full list of articles to ask for, so that I can keep this so that we can get them before the subscription ends. Okay, so what I’m thinking about between now and December 10, that I can make myself available for some study sessions. If you guys have questions, you can come in and ask like, hey, how do I do this, or, you know, kind of ask for some advice on how to do some of that research. And we could run like some of the study sessions. So I can make myself available Monday nights at 7pm Pacific time. And then I feel like Saturday mornings, maybe 11am, might be good. And I can make myself available maybe a little early, a little bit earlier than that, maybe Saturdays at 10am. So we can make those times available, you can come in, ask me questions, that’s just going to be on a case-by-case basis between now and December 10. So you can email me at info@low-sal-life.com. And that goes into my mailbox, and I can give you a link to one of our study sessions. I have a list of topics, I will put it on the blog, low-sal-life.com/blog This video should be pretty much up at the top of that page. And you can click on that. It’ll be a list of research topics. I’m interested in exploring some of them. I’ve done a light study on it, but I’m looking for like the actual research articles that support or deny an idea. So the other thing too, is that these are just things that come up in my own life, like I read about DAO histamine in the intestines. And so like I might do like a few web searches on it, I might find one or two articles on it, but I want to learn a lot more. For example, I have the gene for the low DAO histamine intolerance situation, but I’m not amine sensitive. So I’m curious, like, what’s the correlation between that and salicylate sensitivity? If I manage my amines better will my sis salicylate sensitivity be improved? You know, those are questions I have. But here’s the thing. I don’t have all your guys’s problems, I don’t have MCAS, I don’t have asthma. I don’t have AERD, nasal polyps, although my sinuses were pretty messed up before I went low sal. I don’t have any of those problems. So you guys are the experts in those. So if you guys can look up things related to your sensitivity or your medical condition, and we can gather up some more articles on those. That would be really helpful for when people ask me questions in the future about, Hey, what

13:17

what does it say about this? Okay, so I think that is a good plan. And where we’re at right now, of course, again, life decisions here. Like I’m like, I don’t know, maybe I need to go back to school and find a university that has access to this. I understand why they’re doing it. They’re basically saying, like, if we want to see change, it’s just like organic farming. If we want to see change, we need to stop what we’re doing, and change and pivot and only support open-research, which I 100% support, I don’t think this stuff should be tied up. But in the meantime, there’s going to be growing pains, and unfortunately, we have to live through it. So let’s do our best and collaborate. I will say I can’t give you these articles. But just knowing that there’s value inside of those articles, you know, you could always reach out to the author of the paper and they can share it with you. But it’s pretty common for you guys just ask like, hey, is there any research that supports this? And then I can say yes or no, and, you know, maybe send you screenshots, or the facts or findings, or I can do a video on it.

So I want to show you real quick, just a tool that I use on how I organize my research articles. It’s BibGuru, I believe is what it is. We’ll head over to the computer and I’ll show you how I organized my research articles and the citations and then also how you can download your bibliography, your list of articles with this program and send it to me and then I can just easily upload it to my own bibliography. And it’s super easy, it’s pretty easy for me to see duplicates on there too. And then it’ll be really simple for me to organize my stuff. So let’s get started.

Okay, so the first thing that I would do when I’m doing research on something, and I don’t know where to start, I start on like a major directory that would pull up a lot of articles. So the one that I normally use is actually hosted by Elsevier. And that one is called Sciencedirect.com. I don’t I actually don’t know if there’s a direct link to it. Is that, is there a direct link? Okay, there you go. Yep. So Science Direct, you can certainly look at this without paying, it’s when you actually need to look at the actual full PDF of an article. That’s when you actually need to pay. Just to let you know, most articles are $40 to $60, an article to read. So in one of my videos, I would have about three or four peer-reviewed articles easily to make a point unless I’m actually covering an individual article. So, I would start here keywords, let’s say, salicylate and food. Yeah, let’s just do that. Okay, so then you get a list of articles. And you know, you’re gonna get books, and encyclopedias, and articles. And it doesn’t really matter. But research. Research articles are the most interesting to me, because they’re original research, the other stuff, we’ll still have access to normally. And I have still have university library access. So I can get book chapters and encyclopedia stuff, scans and different articles that way, but we’re talking about original peer-reviewed research articles is what is most interesting, and most helpful. So pardon that train, we’re going to keep going. So this here. This is a research article. I don’t know if I’ve seen this one here, naturally occurring dietary salicylates by Sreepurna. Let’s check that out.

17:27

On my research page and see if I have it here. Yeah, I’ve never seen this one. So we would want to click on it and kind of take a peek at it. Dietary salicylates may have benefits, or adverse symptoms as documented for aspirin to develop dietary strategies. Food is essential but the available literature is limited and controversial. Yes, that is true. This study to apply and validate a reliable methodology to determinate… salicylates and food. Okay, that’s helpful. Great. All right. And you can see that there is no article like no actual information on here. So this, you have to purchase. And so here, you can see that that articles $30 So there’s no way in January that I will have access to this article. And we will either have to make friends that do or find a new place to work at. I don’t know! So okay, here’s the thing. Down here below the article, you can see that this research article is important, and has been cited in 21 other journals that have come out so in the last few years it’s come out Ooh, here’s a view PDF. Oh, just joking. Okay. So these are articles Great, great. Great. Okay. Sometimes there’s a place that shows like all of their citations… Yeah, so this would be one that would absolutely want to check out it’s nice that they have the table still available possibly show full outline. Okay. So this is one that would be locked up. All right. So that one I would absolutely want to know about we’re going to keep this open we’re going to look at one more let’s look at PubMed here salicylate Yeah, let’s look at in household products. I don’t know I’ve never looked this one up. estrogenic potential of salicylate esters and the possible risks in food and cosmetics. Very interesting flavors and fragrance ah Interesting. All right. Let’s just say we want to study salicylates and food, specifically methyl salicylate, that’s like a component in food that is sought after, especially in tea, and wines, like it’s got like this. Light, fleeting, obviously minty, but gives a nice taste. It’s like one of those other flavors like acid in the food, right? So it’s really popular. Look at this. Lots of articles in the last 10 years or so. Okay. Oh, look at that methyl salicylate in wines. All right. So these here are all free, which means that you have access to the full article. Studying methyl salicylate has actually been really helpful for me to understand, like I mentioned fermentation and how different processing of foods can affect salicylate levels. I don’t think we’re limited to just the type or variety of food. I think the way that it’s processed has a really big result in how heavy or not foods are. Okay, so here to date, look this to date, nine different methyl salicylate glycosides. glycosides are like sugar compounds with methyl salicylate have been reported. So these are naturally producing plants. I’m familiar with two or three of them. Okay, so Okay, known as Wintergreen, balsamic, sweet odor. Great, great, great. So what you want to do is you want to go here to this free full text. And then all the way at the bottom, you want to Ooh! look at that pictures. That’s helpful. Methyl salicylate, look at that, oh, none in the viola species. I wonder if they tested the flowers are the actual plant for the fruit seeds. Interesting. Okay. So look at all those different methyl salicylates in bound salicylates for him. I have so much bound salicylate research to do. Okay. Anyway. So going down, moving down, moving down, okay. Even more, this is

22:15

a long article. This looks like a good article. Okay. So down here, the references. This is the gold people! All right. So these are the places where we find those articles. And like I said, if it’s international or before, like the 90s. I just won’t have access to it. So we can look here, you know, not all of these are going to be super helpful. But you know, I mean, that could be, let’s see. glycoside precursors. Let’s look up salicylates down here. There you go. Naturally occurring methyl salicylate glycosides. Yes, I want to read that. Okay. So this here may or may not be in the public domain, but or open source. So we want to add this to our bibliography. So what I do is I go to bigguru, you can log in with a Google login. And you can have different [projects] here. So I’ve never seen this article before. So I made like those because we low-sal-life test, I made a separate bibliography. So basically, you create your new project, low-sal-life test, and then you select your citation. So I do all of mine, I’m a little bit of a environmental, I do most of my stuff and like between biology and environmental, so I use this CSE citation. And so you can select that. And the nice thing here is you can go up to articles and you can put the article name in there. And, you know, if there’s a couple like double check, it’s the same article. So this is the only one looks like it’s the right one. I remember Mau being the name. Okay, so now we’re going to add it, and you can see that it’s added to my list. So you can do a couple different things with this as like the way you want it formatted or whatever. You got a couple different views. This is how I cite my articles in my videos is with this little section here remember Malakar et al you know 2017 That’s where I come up with that. And then this is also actually like this view a lot better. But this here has all the details that you would need in order to cite your literature correctly. Okay, so now I’ve got my article on there and build it out a whole bunch. And the way that you can share it with other scholars is you can download it as bibTeX. All right, so I’m downloading that. I’m going to show you what that looks like. I have one here from before, when I tested it before, okay, so low-sal-life-test.bib. Okay, and then the way that you can that I can upload it to my list of references in the future.

25:29

I can just import it. Let’s see Upload File. bib. Oh, man, I’ve got so much junk in here. I’m so sorry. Low-sal-life. There you go. Okay, and my reference was imported. So what was the name of that? Okay. Apparently, you it’s very limited in the way that it sorts and searches. But you can go down here and you can see that I now have Mau: naturally occurring metal salicylates in my bibliography. This will allow me to go through and download and put this into my collection before my time ends.

Alright, thank you guys so much. Again, if you want to participate in this research review sprint with me on salicylates sensitivity research, please email me at info@low-sal-life.com. And I look forward to the next few months of videos. I’ve got a good plan. I’ve got a good plan coming out. Again, this article review is going to be my top priority over the next six weeks. But I have already filmed a few videos. They’re just – I’m just editing them. So I am pretty sure there’ll be a couple of videos coming out in the next few weeks. As always take care and I’ll talk to you later. Bye

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